The effect of Lactusan on bowel function
OBJECT OF STUDY
RESEARCH METHOD
RESULTS OF THE STUDY
- control group (kefir without lactulose) - 10 children,
- experimental (kefir with lactulose) - 20 children.
To evaluate the results, we used clinical data obtained by direct observation of patients by a doctor, as well as by interviewing parents of sick children, and bacteriological analysis data.
General conclusion on clinical studies of kefir with lactulose produced according to OST 49 29-84, change No. 7:
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- Kefir with lactulose, unlike ordinary kefir, has pronounced bifidogenic properties, that is, it significantly increases the number of bifidobacteria in the microbial pool of the large intestine.
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- Kefir with lactulose very markedly increased the level of lactobacilli, which was not observed in the group taking regular kefir.
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- When taking kefir with lactulose, suppression of pathogenic and conditionally pathogenic microflora is observed.
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- Kefir with lactulose has a positive effect on intestinal function, eliminates constipation and other intestinal disorders in children.
- The use of kefir with lactulose improves the clinical picture: reduces the manifestations of atopic dermatitis, improves appetite, improves the condition after an intestinal infection, improves the general condition of the body and intestinal function after antibiotic therapy.
CONCLUSIONS:
We recommend kefir with lactulose (OST 49 29-84, change No. 7) as a mass product for the prevention of diseases of the gastrointestinal tract, including dysbacteriosis and intestinal dysfunction.From the Department of Children's Diseases of the Peoples' Friendship University of Russia (Department 24 of the Morozov Children's City Clinical Hospital):
| head of department, Doctor of Medical Sciences, Professor |
L. T. Kuzmenko | |
| assistant, Candidate of Medical Sciences |
N.I. Petruk |
From the Department of Urology and Operative Nephrology of the Peoples' Friendship University of Russia (Clinical Hospital 64 in Moscow):
| head of department, Doctor of Medical Sciences, professor, academician of the Academy of Sciences of Ukraine |
V. E. Rodoman | |
| Chief Researcher, Doctor of Biological Sciences |
IN AND. Maksimov |
I certify the signatures of employees of the Peoples' Friendship University of Russia.
| Scientific Secretary of the Academic Council candidate of chemical sciences, professor |
A.P. Krapivko |
APPS
- bifidobacteria (B) - 108 or more,
- lactobacilli (L) - 106-108,
- Escherichia (ESh) - 107-108, of which lactose-negative (LNESH) - 10%,
- hemolytic (HESH) - 2%,
- enterococci (EN) - 105-106,
- Klebsiela (Cl) - <104,
- staphylococci (ST) - <104,
- yeast-like fungi (DG) - <103.
Only those data are entered into the table that differ from the given values, or show dynamics.
- "norm" - regular stool, normal consistency,
- "Sheep feces" - a manifestation of constipation.
To characterize the microflora of feces, measurements were carried out according to 12 of the above indicators. The tables contain data on those indicators that go beyond the above norms or that undergo changes due to the intake of kefir. Those indicators of bakanaliza, which fit into the norm, are not included in the table. The designation “ots (3)” is used when there is no culture of microbes at dilutions for lg KOE = 3.
Table #1
in children who took ordinary kefir (control group).
Dose 200 g per day, course 20 days.
| No. | Name and age of the child | Microflora | bakanal data, lg KOE, % |
Chair feature | Notes | ||
| Before taking kefir | After taking | Before taking kefir | After taking | ||||
| 1 | MM.,
2 years |
L | 8 | ots (6) | norm | norm | |
| 2 | M.A., 3.7 years |
B L ES EN |
7 6 8 8 |
9 7 8 8 |
constipation, stool with mucus | norm | Poor appetite persisted |
| 3 | K.N., 4 years |
B L ES Art. golden |
7 6 6 4 |
8 6 7 ots (3) |
constipation | stool every other day | Recurrent bronchitis |
| 4 | Z.K., 5 years |
B L E W |
7 5 5 |
7 <5 6 |
constipation | stool every other day | Moderate manifestation of dermatitis remained |
| 5 | M.A., 6 years |
L ES LNESH staph |
8 54 |
ots (3) 3 83% 4 |
"sheep feces" | norm | |
| 6 | N.J., 7 years |
L ES |
8 5 |
ots (6) | norm | norm | |
| 7 | K.N., 7 years |
L | 8 | ots (6) | "sheep feces" every other day | norm | |
| 8 | B.N., 8 years |
L | 7 | 7 | constipation | norm | Bronchial asthma |
| 9 | R.A., 10 years |
B L |
7 <6 |
8 <6 |
constipation | norm | Persistent toxicoplasma infection |
| 10 | K.O., 11 years |
EN | 7 | norm | norm | ||
In the second group, where kefir was taken with a 0.5% lactulose supplement "Lactusan", 20 children from 1 to 12 years old. In 9 children (47 %) in the experimental group, the level of bifidoflora after the course of kefir with lactulose "Lactusan" increased, but in three children (15 %), who suffered viral and other diseases during the intake, it decreased by 1 log unit. An increase in the level of lactobacilli was observed in 13 children (65 %), and in three (15 %) a slight decrease was observed. Against the background of taking kefir with lactulose, there was a noticeable cleansing of the intestines from opportunistic flora (hemolytic, low-fermenting and other forms, as well as Proteus, Klebsiella, staphylococci and others).
Table number 2
in children taking kefir with 0.5% lactulose supplement
"Laktusan" (experimental group). Dose 200 g per day, course 20 days
| No. | Name and age of the child | Microflora | bakanal data, lg KOE, % |
Chair feature | Notes | ||
| Before taking kefir | After taking | Before taking kefir | After taking | ||||
| 1 | M.I., 11 months |
B L cl Citrobacter Art. golden Art. hemolith. |
6 <6 <6 |
8 6 ots (5) 5 4 100% |
Stool with mucus and undigested lumps | norm | Reception on the background of SARS. Appetite improvement |
| 2 | HELL.., 1 year |
L cl EN |
<6 5 7 |
8 ots (5) 4 |
The chair is liquid, 3-4 times a day with undigested lumps | norm | Reception on the background of SARS. Appetite improvement |
| 3 | G.V., 1 year |
B L EN PC cl |
5 ots(6) 6 <3 6 |
6 6 9 ots (3) ots (3) |
Mushy with mucus and undigested lumps, tendency to constipation | norm | Atopic dermatitis. Previously, before taking kefir with lactulose, he was treated with phage for dysbacteriosis |
| 4 | F.K., 1 year 10 months |
B L cl AP |
8 6 4 5 |
9 7 ots(4) ots(4) |
Mushy with mucus and undigested lumps, tendency to constipation | norm | Decreased symptoms of atopic dermatitis |
| 5 | A.R., 2 years |
L ES |
5 6 |
7 7 |
mushy, green | norm | Bronchial asthma |
| 6 | F.P., 3 years |
norm | norm | Constipation, stool with mucus | norm | Decreased manifestation of atopic dermatitis | |
| 7 | B.A, 3 years |
B L ES GESH Proteus |
9 7 <6 7 6 |
8 8 8 4 ots(3) |
Dysbacteriosis for a long time | norm | Decreased manifestation of atopic dermatitis |
| 8 | M.E, 3 years 5 months |
B L St. Epidermis |
9 7 7 |
9 8 ots (3) |
constipation | norm | Reception in two stages: kefir without lactulose - there was constipation, then switching to taking kefir with lactulose - the stool returned to normal |
| 9 | A.A., 4 years |
L ES GESH ST |
8 5 No 4 |
ots (6 ) 8 100% ots (4) |
Unstable | norm | Presumably food poisoning at the end of the course |
| 10 | S.V., 4 years |
L LNESH EN P |
ots (6) No 7 8 |
ots (6) 5% 7 8 |
Intestinal colic, tendency to constipation | norm | Appetite improvement |
| 11 | B.S., 6 years |
AP | 4 | ots (3) | Constipation, abdominal pain | norm | Had an intestinal infection and recovered in 1 day |
| 12 | P.D., 6 years |
EN P DG |
6 ots (3) 3 |
7 8 ots (3) |
"sheep feces" | norm | He had been ill with bronchitis at the end of treatment, received antibiotic therapy |
| 13 | K.K., 6 years |
B L ES |
8 6 10 |
9 8 10 |
constipation | norm | Dysbacteriosis from birth, decreased manifestation of atopic dermatitis |
| 14 | G.O., 7 years |
B L ES |
8 7 8 |
7 6 7 |
constipation | norm | Bronchial asthma, had a viral disease before the second bacanalysis |
| 15 | K.K., 7 years |
L | 5 | <6 | norm | norm | Reception in two stages: kefir without lactulose gave the elimination of constipation, taking kefir with lactulose led to an increase in the level of lactobacilli |
| 16 | K.K., 7 years |
B L ES |
8 7 8 |
9 8 5 |
"sheep feces" | norm | |
| 17 | Ch.M., 7 years |
B L EN |
ots (7) ots (6) 7 |
9 8 ots (6) |
"sheep feces" | norm | |
| 18 | I.A., 8 years |
B L |
6 6 |
7 8 |
constipation | norm | Chronic pyelonephritis. Appetite improvement |
| 19 | V.T., 9 years |
B L ES |
8 8 8 |
9 6 7 |
constipation | in one day | Recurrent obstructive bronchitis |
| 20 | K.D., 12 years |
B L ES Art. solotis. |
7 6 6 4 |
9 7 8 ots (3) |
constipation | norm | Rheumatoid arthritis |
GV, 1 year old, had dysbacteriosis of the 2nd degree and at low levels of lacto- and bifidobacteria, had a markedly high level of Klebsiella (lg COE = 6). This child was treated with phage, but there was no improvement. The course of treatment with kefir with "Lactusan" led to the disappearance of Klebsiella and an increase in the number of bifido- and lactoflora.
Significant improvements were observed in the clinic, when the disturbances in the intestinal function disappeared and the stool returned to normal. In two other cases, when children before treatment had a reduced level of bifido- and lactoflora (K.K., 7 years old and Ch.M., 7 years old), complete normalization of the microflora was achieved, and the tendency to constipation disappeared and the stool returned to normal.
In some cases, the effect of kefir turned out to be insufficient and an additional course of kefir with lactulose "Lactusan" was required.
In the child K.K., 7 years old, kefir contributed to the elimination of constipation, however, its effect on the composition of the microflora was not sufficiently effective, because. lactobacilli remained at a very low level. After a course of kefir with lactulose, the level of lactoflora increased from < 5 to 6.
In another child (M.E., 3.5 years old), a course of kefir led to constipation, and this child was transferred to the experimental group receiving kefir with lactulose "Lactusan". Achieved normalization of stool and improvement of microflora composition.
Three children had atopic dermatitis. After a course of kefir with lactulose, its manifestations decreased sharply. In one child (P.D., 6 years old), after a course of kefir with "Lactusan", there was an increase in the level of proteus (up to lg KOE = 8), which is explained by the postponement of bronchitis at the end of treatment and antibiotic treatment.
Similarly, in a child (A.A., 4 years old) due to food poisoning at the end of the course, the level of Escherichia increased (up to lg COE = 8) by 100% due to hemolytic forms. However, in all these cases, the general condition of the child improved, the stool returned to normal, and the main indicators of bacillary tests were at the level of normal values.
The beneficial effect of kefir with lactulose "Lactusan" in comparison with kefir without additives can be judged by the content of bifidus and lactobacilli in feces (Table 3).
For a complete correctness of the comparison of the action of kefir made according to traditional technology, and kefir enriched with lactulose, other equal conditions should be observed. For a correct comparison, the statistics did not take into account the data of the bacteriological examination of children who had diseases (ARVI, food poisoning, and others) while taking the products whose effect is being studied, because. it was the past diseases that could make unfavorable adjustments to the composition of the microflora.
Table 3 compares the data of children, all other things being equal.
Table number 3.
treated with regular kefir (control group) and kefir,
enriched with lactulose "Lactusan" (experimental group)
| group of children | bifidobacteria | lactobacilli | ||
| promotion | downgrade | promotion | downgrade | |
| Control (kefir), 10 people |
20 % | 0 | 20 % | 50 % |
| Experienced (kefir with lactulose "Laktusan"), 19 people |
47 % | 5 % | 65 % | 5 % |
If in the control group an increase in the level of bifidobacteria was only in 20 % children, then in the experimental group, who took kefir with lactulose, it was in 47 %. In the change in the level of lactobacilli, the difference is even greater - 20 % versus 65 %, respectively. Ordinary kefir caused a decrease in lactobacilli in 50 % children, which sometimes exceeded 100-fold, while kefir with lactulose - only in 1 person (5 %). At the same time, the stool in the experimental group returned to normal in all (100 %) children.

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