{"id":3110,"date":"2019-05-13T09:10:46","date_gmt":"2019-05-13T09:10:46","guid":{"rendered":"https:\/\/lactusan.ua\/?p=3110"},"modified":"2019-05-13T09:10:46","modified_gmt":"2019-05-13T09:10:46","slug":"issledovanie-laktulozy-na-primenenie-pri-zabolevaniyax-pecheni-i-zaporax","status":"publish","type":"post","link":"https:\/\/lactusan.com.ua\/en\/issledovanie-laktulozy-na-primenenie-pri-zabolevaniyax-pecheni-i-zaporax\/","title":{"rendered":"Study of lactulose for use in liver disease and constipation"},"content":{"rendered":"

Perm Central City Clinical Hospital No. 2 Z.N. BAISHEVA<\/p>\n

Head Gastroenterological department of the Perm Central Clinical Hospital No.<\/p>\n

About the use of Lactusan in liver disease and chronic constipation<\/strong><\/p>\n

Lactulose, the active ingredient of Lactusan, is a synthetic disaccharide, under the influence of which Lact reproduces. acidophilis and Lact. bifidus in the large intestine. Due to this, the growth of putrefactive and other pathogenic microbes is suppressed.<\/p>\n

Under the action of the drug, the formation of nitrogen-containing substances in the proximal colon decreases and, accordingly, their absorption into the systemic circulation.<\/p>\n

Based on these data, the drug should be prescribed for chronic hepatic encephalopathy and intestinal dysbacteriosis, characterized by a decrease or absence of lactobacilli and an excess of putrefactive microflora.<\/p>\n

The study was conducted in the gastroenterological department of the 2nd Central Clinical Hospital in Perm.<\/p>\n

The study included 26 patients aged 46 to 54 years, who were divided into 2 groups:<\/p>\n

    \n
  1. Patients with chronic cryptogenic hepatitis and cirrhosis of the liver with chronic hepatic encephalopathy - 11 people (7 men and 4 women).<\/li>\n
  2. Patients with persistent constipation, in whom the study of feces for dysbacteriosis revealed a decrease in lactobacilli (in 5 patients) or their complete absence (in 10 patients) and the presence of putrefactive microbes in 6 out of 15 patients.<\/li>\n<\/ol>\n

    Patients with hepatic encephalopathy were given Lactusan syrup, 3 tablespoons (45 ml) 2 times a day for 15 days. The dynamics of clinical signs of encephalopathy and transaminases was assessed. It was noted that after the course of therapy, the phenomena of encephalopathy decreased in all patients, no significant dynamics of transaminases was detected, although in 6 patients a slight decrease was noted.<\/p>\n

    In the 2nd group of patients with intestinal dysbacteriosis, Lactusan was prescribed 1 tablespoon (15 ml) 1-2 times a day. Already on the 5th-7th day, normalization of the stool was noted in all 15 patients. With continued treatment, 6 people developed a tendency to diarrhea, which was stopped by reducing the dose of the drug by half.<\/p>\n

    Re-examination of feces for dysbacteriosis was carried out 2 weeks after discontinuation of the drug. In 12 people, the number of lactobacilli and bifidobacteria reached normal levels (1010). No putrefactive microflora was found in any of the patients.<\/p>\n

    During the study period, no phenomena of poor tolerance of the drug were noted - nausea, vomiting, abdominal pain.<\/p>\n

    FINDINGS<\/p>\n

    The use of Lactusan for 2 weeks by patients with chronic hepatic encephalopathy can reduce the clinical manifestations of encephalopathy. There is also a positive dynamics of symptoms in patients suffering from dysbacteriosis with the normalization of the microbial spectrum of the colon.<\/p>\n

    It is possible to recommend taking Laktusan in gastroenterological practice for patients with chronic liver diseases with symptoms of hepatic encephalopathy and for patients with chronic persistent constipation caused by dysbacteriosis with a decrease in the number of lactobacilli. The drug is well tolerated by patients, so it can be used both in a hospital and on an outpatient basis.<\/p>","protected":false},"excerpt":{"rendered":"

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